Mairead McGuinness was formally nominated as a European election candidate for the party, along with Jim Higgins MEP, in Athlone on Sunday.
McGuiness is regarded as one of the strongest candidates in the field in the Euro elections which take place in May.
She is leader of the Fine Gael delegation in the European Parliament, has played a key role in reform of the Common Agricultural Policy (CAP).
There was speculation that she would be restricted to canvassing in north Leinster and Cavan-Monaghan. But now she will not campaign in Mayo, Mr Higgins’s home county, and he will stay away from Meath, which is regarded as her home territory, even though she comes from Ardee.
There are 15 counties in the constituency, but she told the convention that she had every confidence that Fine Gael could win two seats in the constituency in the elections on 23 May.
“The issues to dominate the elections will be the economy, jobs and growth,” she said. “The economic crisis has forced us to reassess and analyse our relationship with Europe. The challenge for the future is to rebuild a Europe of solidarity between nations.”