The N2 is closed between Ardee and Carrickmacross at Churchtown, following a serious multi-vehicle collision this morning.
The road is closed between McCabes roundaout and Reaghstown as technical examinations are taking place following the crash that happened this morning.
Traffic diversions are in place.
Motorists are advised to avoid the area if possible, though the road is expected to be opened later this afternoon.
*UPDATE: Two people were taken to Our Lady of Lourdes Hospital for treatment following the crash which happened at approximately 10am this morning. Their condition is not known at present.
The collision involved four vehicles, believed to be cars.
Gardaí are appealing to witnesses to the crash to come forward.